GEL POTENTIAL OF RED ONION (Allium cepa L.) ETHANOL EXTRACT AS ANTIFUNGAL CAUSE TINEA PEDIS

Erza, Genatrika and Elza, Sundhani and Mayang, Ika Oktaviana (2020) GEL POTENTIAL OF RED ONION (Allium cepa L.) ETHANOL EXTRACT AS ANTIFUNGAL CAUSE TINEA PEDIS. ARTIKEL JURNAL.

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Abstract

Introduction: Tinea pedis is a dermatophyte infection of the foot, especially between the fingers and soles of the feet. Tinea pedis is caused by a fungal infection of Trichophyton rubrum. Red onion is one of the spices that has been widely known by the public and has been used as a traditional medicine in the prevention of fungus. The objective of this research was to determine the antifungal activity of gel from an extract of red onion on Trichophyton rubrum. Materials and Methods: The gel was formulated with various concentration of red onion, FI with a concentration of extract (5%), F2 (7,5%) and F3 (12,5%). Each formula was tested the physical characteristics and antifungal activity toward T.rubrum. The antifungal activity was determined by the agar well diffusion method using SDA plates. Furthermore, the antifungal activities were assessed by the presence or absence of inhibition zones after the plates were incubated at 28oC for 7 days. Results: F3 has the greatest inhibitory power than F1 and F2 (p<0,05). Then, F3 has the same inhibitory power as a positive control (p>0,05). Discussion: All gel understudy at various concentrations of red onion formulated in gel exhibited antifungal activity. Antifungal activity of red onion because it is containing Allicin. Therefore we can use these gel as a natural antifungal in the healing of tinea pedis caused T.rubrum. Conclusion: The gel from an extract of red onion showed significant antifungal activity against T.rubrum.

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