Formulation of Nanoparticles of Ethanol Extract of Garcinia mangostana L. Leaves as Antioxidant with Pectin as Cross-Linker and Chitosan Variation as Polymer

Diniatik, Diniatik and Anis, Kusumawati and Agus, Siswanto and Zaim Firdaus, Imtihan and Aji, Wahyudi (2019) Formulation of Nanoparticles of Ethanol Extract of Garcinia mangostana L. Leaves as Antioxidant with Pectin as Cross-Linker and Chitosan Variation as Polymer. PEER REVIEW.

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Abstract

G. mangostana leaves contained xanthone substances, it could be used as antioxidants. Ethanolic extract of G. mangostana leaves were formulated into nanoparticles compound which were made available into nano size through ionic gelation method. G. mangostana leaves were extracted by using maceration method with 50% ethanol as solvent, then were continued with evaporation until thick extract were formed. The nanoparticle formulas were made by mixing G. mangostana extract in ethanol, a solution of chitosan in glacial acetic acid as polymer, and pectin as a cross-linker solution. There were three formulas (1,2,3) used, with the difference in pectin concentration which were 0.005; 0.01; and 0.02. Characterization of the three formulas include transmittance values were used spectrophotometric method and particle sizes by using particle size analysis (PSA). The results of this research showed that the transmittance of formulations 1, 2 and 3 were 95.9%; 97.7% and 97.3%. The highest transmittance value was formula 3, then were analysed its particle size and zeta potential were 2280 nm and -20.6 mV

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