Formulation of Metformin Hydrochloride Floating Tablet With HPMC K4m Cr And Sodium Bicarbonate

Agus, Siswanto and Suparman, Suparman and Rudi, Kusuma Werdana (2016) Formulation of Metformin Hydrochloride Floating Tablet With HPMC K4m Cr And Sodium Bicarbonate. PEER REVIEW.

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Abstract

Metformin HCl is an anti-hyperglycemic agent used in the treatment of non-insulin dependent diabetes mellitus. It has been reported that oral bioavailability of metformin HCl is 50-60 % due to its selective absorption from upper part of gastrointestinal tract. It has biological half-life of 1.7 hours, hence the development of floating drug delivery system is recommended in order to enhance the bioavailability. The aim of this study was to determine the optimum formula of metformin HCl floating tablet. The tablets were prepared by wet granulation technique, using HPMC K4M CR as hydrophilic polymer and sodium bicarbonate as a gas-generating agent. A 2 factorial design was applied to optimize the formula of metformin HCl floating tablet. The amounts of HPMC K4M CR (X 1 ) and sodium bicarbonate (X ) were selected as independent variables.The optimum formula was determined based on numeric method with floating lag time, 2 total floating time, and the drug dissolution for 1, 3, 10 hours as independent variables. The optimum formula was shown by the greatest desirability value (0.672) with the compositions of 179.38 mg HPMC K4M CR and 37.5 mg sodium bicarbonate.

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