The cost effectiveness of HPV vaccination in addition to screening a Dutch perspective

Didik, Setiawan (2018) The cost effectiveness of HPV vaccination in addition to screening a Dutch perspective. ARTIKEL JURNAL.

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Abstract

Addition of the Human Papillomavirus (HPV) vaccine to available cytological screening has been proposed to increase HPV-related cancer prevention. A comprehensive review on this combined strategy implemented in the Netherlands is lacking. For this review, we therefore analysed all relevant studies on cost-effectiveness of (worldwidescience.org) HPV vaccines in combination with cervical screening in the Netherlands. Most of the studies agree that vaccination in pre-sexual-activity periods of life is cost-effective. Based on published sensitivity analyses, the incremental cost-effectiveness ratio was found to be mainly driven by vaccine cost and discount rates. Fewer vaccine doses, inclusion of additional benefits of these vaccines to prevent HPV-related non-cervical cancers as well, and vaccination of males to further reduce the burden of HPV-induced cancers are three relevant options suggested to be investigated in upcoming economic evaluations.

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