Design and Optimization of Self Nano-Emulsifying Drug Delivery System Containing a New Anti-inflammatory Agent Pentagamavunon-0

Ika Yuni, Astuti and Marchaban, Marchaban and Ronny, Martien and Agung Endro, Nugroho (2017) Design and Optimization of Self Nano-Emulsifying Drug Delivery System Containing a New Anti-inflammatory Agent Pentagamavunon-0. PEER REVIEW.

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Abstract

Pentagamavunon-0 is a potent anti-inflammatory drug. The oral bioavailability of PGV-0 is very low due to itslow solubility in water. The aim of this study is to design and optimize SNEDDS formulation to improve dissolution ofPGV-0 by Simplex Lattice Design. The independent variables were the amounts of oleic acid (X1), Tween 20 andlabrasol (X2), and PEG 400 (X3). The dependent variables were droplet size (Y1), the concentration of PGV-0dissolved in the 45thmin (C45) (Y2) and solubility of PGV-0 (Y3) fitted to a quadratic model. The equation, contourplots, and overlay plot were constructed to determine the optimum formulation and to understand the responses tovarious combinations of components. The optimum formulation of SNEDDS consists of 18.6% oleic acid, 51.4%Tween 20:labrasol 1:1 and 30% PEG 400. The C45of the optimum formulation is 82.20%, significantly higher thanunmodified PGV-0. The droplet size is 75.45 nm and solubility of PGV-0 is 31.80 mg/mL. The predicted values arenot significantly different with the experimental values. The amount of oleic acid is the most influential factor toincrease droplet size and decrease the C45. The most influential factor to increased C45is the amount of PEG 400.

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