Study of Anti-Aging Effectiveness and Irritation of Day Cream Containing Tetrahydrocurcumin

Ika, Yuni Astuti and Diah, Ardiana and Agus, Siswanto and Wahyu, Utaminingrum and Arif, Budiman (2018) Study of Anti-Aging Effectiveness and Irritation of Day Cream Containing Tetrahydrocurcumin. PEER REVIEW.

	Text (Peer Review) Study of Anti-Aging Effectiveness and Irritation of Day Cream Containing.pdf Download (4MB)
	Text (Similarity - Ika Yuni Astuti) 9. Study of Anti-Aging Effectiveness and Irritation of Day Cream Containing Tetrahydrocurcumin.pdf Download (2MB)
	Text (Similarity - Agus Siswanto) Study of Anti-Aging Effectiveness and Irritation of Day Cream Containing Tetrahydrocurcumin.pdf Download (3MB)
	Text (Korespondensi) Bukti Korespondensi Study of Anti-Aging Effectiveness and Irritation of Day Cream Containing Tetrahydrocurcum.pdf Download (249kB)

Abstract

Aim: The aim of this study was to determine the anti-aging effectiveness and the irritation effect of a day cream containing tetrahydrocurcumin. Methods: The anti-aging activity test used a pre-test post-test control group design in mice (Mus musculus L.). The shaved dorsal skin of the mice was applied with the tested creams, i.e the cream contain tetrahydrocurcumin (THC), ethyl ascorbyl ether (positive control, PC), and the cream base (negative control, NC). At 2 hours before and 15 minutes after UV irradiation, the sensitivity, collagen level, elasticity, and water content of the skin was measured by a skin analyzer. This process was repeated daily in 8 weeks. The skin condition at the beginning and at the end of the treatment was compared. The irritation test of THC, PC, and NC used a HET-CAM method. The hemorrhage time, lysis time, and coagulation time of the hen’s egg was calculated using irritation score (IS) to get irritation index value. Results: The group with the cream containing THC treatment showed a significant difference in sensitivity, collagen level, elasticity, and water content before and after the treatment (p ≤ 0.05). PC and THC showed no sensitivity (0 mm2 of erythema). THC showed the highest collagen level (80.17±6.4%), elasticity (66±6.07%), and water content (22±2.32%). Conclusion: Based on the scores of all the anti-aging parameters, the THC cream had the same anti-aging effectiveness as PC and more effective than NC. The cream containing THC was effective as an anti-aging and was not irritate.

Actions (login required)

View Item