Health-Related Quality of Life of Patients with HPV-Related Cancers in Indonesia

Didik, Setiawan (2018) Health-Related Quality of Life of Patients with HPV-Related Cancers in Indonesia. ARTIKEL JURNAL.

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Abstract

Background HPV-related cancer becomes a serious concern in developing countries. Valid estimates of a country-specific health-related quality of life (worldwidescience.org) (HRQoL) for patients with HPV-related cancers provide a substantial tool in determining the burden of the disease. Methods HRQoL of patients with HPV-related cancers (cervical, uterine, nasopharyngeal, head and neck, and anogenital cancer) was assessed using the EQ-5D questionnaire. (worldwidescience.org) Validity and reliability were assessed by means of construct validity and test-retest reliability methods, respectively. Subsequently, the EQ-5D utility index was calculated using the Thailand value set. Results The EQ-5D questionnaire came out as a valid and reliable questionnaire for measuring HRQoL of patients with HPV-related cancers in Indonesia. From a total of 520 patients diagnosed with HPVrelated cancers, 404 patients were excluded due to inclusion criteria and finally 116 patients participated in the study. Mean age of the patients was 47.5 years (SD=12.03). Most of the patients were female (56.0%), married (97.4%), and less than (worldwidescience.org) half of them had finished high school (32.7%). Moreover, the proportions of nasopharyngeal, cervical, head and neck, anogenital, and uterine cancers in the study population were 29.3%, 24.6%, 22.4%, 14.2% and 9.5%, respectively. The average HRQoL of the HPV-related cancers was 0.69 (SD 0.10) with the highest and lowest estimates applying to uterine cancer (0.84 ± 0.29) and head-and-neck cancer (0.58 ± 0.33), respectively. Conclusion In comparison to existing reference utility index for healthy population, HRQoL of patients with HPV-related cancers was found to be reduced to a certain extent in our study for Indonesia.

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