Physical Characterization and Dissolution Study of Pentagamavunon-0 Loaded Self Nano-Emulsifying Drug Delivery System

Ika Yuni, Astuti and Marchaban, Marchaban and Ronny, Martien and Agung Endro, Nugroho (2018) Physical Characterization and Dissolution Study of Pentagamavunon-0 Loaded Self Nano-Emulsifying Drug Delivery System. PEER REVIEW.

	Text (Peer Review) 8. Physical Characterization and Dissolution Study of Pentagamavunon-0 Loaded Self Nano-Emulsifying Drug Delivery SystemNama Penulis.pdf Download (375kB)
	Text (Similarity) 8. Physical Characterization and Dissolution Study of Pentagamavunon-0 Loaded Self Nano-Emulsifying Drug Delivery System.pdf Download (1MB)
	Text (Korespondensi) Bukti Korespondensi Physical Characterization and Dissolution Study of Pentagamavunon-0 Loaded Self Nano-Emulsifying Drug Delivery System.pdf Download (346kB)

Abstract

The recent work focuses on the physical characterization and dissolution study of PGV-0 loaded self-nanoemulsifying drug delivery system (SNEDDS). The PGV-0 SNEDDS was prepared by spontaneous emulsification method using oleic acid, tween 20:labrasol (1:1) and polyethylene glycol 400. The zeta potential of the PGV-0 SNEDDS was -34.4±7.66 mv. The nanoemulsion of PGV-0 SNEDDS was thermodynamically stable with forming droplet oil containing PGV-0 in it and spherical. The dissolution result showed that the dissolution profile of SNEDDS PGV-0 was dissimilar with the PGV-0 powder in AGF and AIF. The PGV-0 SNEDDS was able to increase the dissolution significantly.

Actions (login required)

View Item