Molecular Docking of Gnetin C and Transresveratrol of Melinjo Seeds (Gnetum Gnemon L.) Used as the Inhibitors of Breast Cancer Cells MCF-7

Kintan Nur, Romadhona and Nenden Aulia, Shifa and Asmiyenti Djaliasrin, Djalil (2018) Molecular Docking of Gnetin C and Transresveratrol of Melinjo Seeds (Gnetum Gnemon L.) Used as the Inhibitors of Breast Cancer Cells MCF-7. PEER REVIEW.

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Abstract

Breast cancer is a cancer caused by uncontrolled cell growth in breast tissue. In this research, molecular docking has been studied to predict binding affinity of Gnetin C dan trans-resveratrol as active compunds of melinjo seeds to inhibit breast cancer cells Michigan Cancer Fondation-7 (MCF-7). Molecular docking was performed by autodock-vina. The result indicated that Gnetin C and tans-reserveratrol can bind the same amino acid as natural ligan of MCF-7 such as VAL 54B, VAL54B, TYR 55B, TYR 216B, TRP 227B, LEU 306B, LEU 306B, and LEU 306B. Binding affinity of Gnetin C and transresveratrol was -6. and -7.9 respectively, while the natural ligan was -10.0. It means Gnetin C and trans-reserveratrol can bind the protein acid of MCF-7 although the docking energy was lower than the natural ligan. Based on this research, Gnetin C and trans-reserveratrol are potential as anticancer and chemoprevention because they can inhibit some amino acid of cancer cells MCF-7.

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