Assessment of the broader economic consequences of HPV prevention from a governmentperspective: A fiscal analytic approach

Didik, Setiawan (2018) Assessment of the broader economic consequences of HPV prevention from a governmentperspective: A fiscal analytic approach. REPORT OF THE PLAGIARISM CHECK.

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Abstract

Background: HPV infection poses a substantial burden in terms of morbidity, mortality, and economic losses, especially in low/middle-income countries. HPV vaccination and/or cervical cancer screening among females may reduce the burden of HPV-related diseases. However, limited funds may impede the implementation of population-based programmess. Governmental investments in the prevention of infectious disease may have broader economic and fiscal benefits, which are not accounted for in conventional economic analyses. This study estimates the broader economic and fiscal impacts of implementation of HPV vaccination and/or cervical cancer screening in Indonesia from the perspective of the government. Methods: A government-perspective quantitative analytic framework was applied to assess the Net Present Value (NPV) of investment on cervical cancer prevention strategies including HPV vaccination, cervical screening and its combination in Indonesia. Results: Based on a cohort of 10,888,500 Indonesian 12-year-old females, it was estimated that HPV vaccination and/or cervical cancer screening result in a positive NPV for the Indonesian government. The combination of cervical screening and HPV vaccination generated a substantial reduction of cervical cancer incidence and HPV-related mortality of 95,668 and 21,079, respectively. It was estimated that HPV vaccination in combination with cervical screening is the most favorable option for cervical cancer prevention (NPV I$2.212.310.000), followed by HPV vaccination alone (NPV I$2.026.113.000) and cervical screening alone (NPV I$408.584.000). Conclusion: In addition to clinical benefits, investing in HPV vaccination and cervical screening may yield considerable fiscal benefits for the Indonesian governments due to lifelong benefits resulting from reduction of HPV-related morbidity and mortality.

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